Vincaria®
(1) Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].BMC Complement Altern Med. 2007 Oct 31;7:34. http://www.ncbi.nlm.nih.gov/pubmed/17974032
(2) Piscoya J, Rodriguez Z, Bustamante SA et al: Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442-8.http://www.ncbi.nlm.nih.gov/pubmed/11603848
(3) Miller MJ, Mehta K, Kunte S et al: Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond). 2005 Oct 21;2:11. http://www.ncbi.nlm.nih.gov/pubmed/16242032
(4) Sandoval M, Okuhama NN, Zhang XJ et al: Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002 May;9(4):325-37. http://www.ncbi.nlm.nih.gov/pubmed/12120814
(5) J. F. Gmelin, Carvalho MV, Penido C et al: Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet). Inflammopharmacology. 2006 Mar;14(1-2):48-56.http://www.ncbi.nlm.nih.gov/pubmed/16835713
(6) Miller MJ, Ahmed S, Bobrowski P et al: The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006 Apr 7;6:13. http://www.ncbi.nlm.nih.gov/pubmed/16603065
(7) Correia AF, Segovia JF, Gonçalves MC et al: Amazonian plant crude extract screening for activity against multidrug-resistant bacteria. Eur Rev Med Pharmacol Sci. 2008 Nov-Dec;12(6):369-80.http://www.ncbi.nlm.nih.gov/pubmed/19146199
(8) Urdanibia I, Michelangeli F, Ruiz MC et al: Anti-inflammatory and antitumoural effects of Uncaria guianensis bark. J Ethnopharmacol. 2013 Dec 12;150(3):1154-62. http://www.ncbi.nlm.nih.gov/pubmed/24212077
(9) Dietrich F, Kaiser S, Rockenbach L et al: Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line. Food Chem Toxicol. 2014 May;67:222-9. http://www.ncbi.nlm.nih.gov/pubmed/24607820
(10) Caon T, Kaiser S, Feltrin C et al: Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food Chem Toxicol. 2014 Apr;66:30-5.http://www.ncbi.nlm.nih.gov/pubmed/24447975
(11) Lima-Junior RS, Mello Cda S, Siani AC et al: Uncaria tomentosa alkaloidal fraction reduces paracellular permeability, IL-8 and NS1 production on human microvascular endothelial cells infected with dengue virus. Nat Prod Commun. 2013 Nov;8(11):1547-50. http://www.ncbi.nlm.nih.gov/pubmed/24427938
(12) Kaiser S, Dietrich F, de Resende PE et al: Cat’s claw oxindole alkaloid isomerization induced by cell incubation and cytotoxic activity against T24 and RT4 human bladder cancer cell lines. Planta Med. 2013 Oct;79(15):1413-20. http://www.ncbi.nlm.nih.gov/pubmed/23975868
(13) Shi Z, Lu Z, Zhao Y et al: Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. Neurochem Int. 2013 Jun;62(7):940-7.http://www.ncbi.nlm.nih.gov/pubmed/23500604
(14) Dreifuss AA, Bastos-Pereira AL, Fabossi IA et al: Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity. PLoS One. 2013;8(2):e54618. http://www.ncbi.nlm.nih.gov/pubmed/23408945
(15) Mur E, Hartig F, Eibl G, Schirmer M: Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol. 2002 Apr;29(4):678-81. http://www.ncbi.nlm.nih.gov/pubmed/11950006
(16) Rojas-Duran R, González-Aspajo G, Ruiz-Martel C et al: Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. J Ethnopharmacol. 2012 Oct 11;143(3):801-4.http://www.ncbi.nlm.nih.gov/pubmed/22846434
(17) Santos Araújo Mdo C, Farias IL, Gutierres J et al: Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial. Evid Based Complement Alternat Med. 2012; 2012:676984.http://www.ncbi.nlm.nih.gov/pubmed/22811748
(18) Bors M, Michałowicz J, Pilarski R et al: Studies of biological properties of Uncaria tomentosa extracts on human blood mononuclear cells. J Ethnopharmacol. 2012 Aug 1;142(3):669-78.http://www.ncbi.nlm.nih.gov/pubmed/22683905
(19) Akhtar N, Miller MJ, Haqqi TM et al: Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC Complement Altern Med. 2011 Aug 19;11:66. http://www.ncbi.nlm.nih.gov/pubmed/21854562
(20) Guthrie OW, Gearhart CA, Fulton S et al: Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. Brain Res. 2011 Aug 17;1407:97-106.http://www.ncbi.nlm.nih.gov/pubmed/21762882
(21) Domingues A, Sartori A, Golim MA et al: Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? J Ethnopharmacol. 2011 Sep 1;137(1):635-42.http://www.ncbi.nlm.nih.gov/pubmed/21718770
(22) Bors M, Bukowska B, Pilarski R et al: Protective activity of the Uncaria tomentosa extracts on human erythrocytes in oxidative stress induced by 2,4-dichlorophenol (2,4-DCP) and catechol. Food Chem Toxicol. 2011 Sep;49(9):2202-11. http://www.ncbi.nlm.nih.gov/pubmed/21712061
(23) Domingues A, Sartori A, Valente LM et al: Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile. Phytother Res. 2011 Aug;25(8):1229-35.http://www.ncbi.nlm.nih.gov/pubmed/21656603
(24) Miller AK, Benson JM, Muanza DN et al: Anti-inflammatory effects of natural product formulations on murine dendritic cells. J Diet Suppl. 2011 Mar;8(1):19-33. http://www.ncbi.nlm.nih.gov/pubmed/21399725
(25) Anter J, Romero-Jiménez M, Fernández-Bedmar Z et al: Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. J Med Food. 2011 Mar;14(3):276-83.http://www.ncbi.nlm.nih.gov/pubmed/21182433
(26) Gurrola-Díaz CM, García-López PM, Gulewicz K et al: Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway. Phytomedicine. 2011 Jun 15;18(8-9):683-90.http://www.ncbi.nlm.nih.gov/pubmed/21156346
(27) Nogueira Neto J, Coelho TM, Aguiar GC et al: Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat’s claw) extract. Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):205-8.http://www.ncbi.nlm.nih.gov/pubmed/21030132
(28) Herrera DR, Tay LY, Rezende EC et al: In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogens. J Oral Sci. 2010 Sep;52(3):473-6.http://www.ncbi.nlm.nih.gov/pubmed/20881342
(29) Pilarski R, Filip B, Wietrzyk J et al: Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition. Phytomedicine. 2010 Dec 1;17(14):1133-9.http://www.ncbi.nlm.nih.gov/pubmed/20576410
(30) Dreifuss AA, Bastos-Pereira AL, Avila TV et al: Antitumoral and antioxidant effects of a hydroalcoholic extract of cat’s claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. J Ethnopharmacol. 2010 Jul 6;130(1):127-33. http://www.ncbi.nlm.nih.gov/pubmed/20435132
(31) Rinner B, Li ZX, Haas Het al: Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer Res. 2009 Nov;29(11):4519-28.http://www.ncbi.nlm.nih.gov/pubmed/20032400
(32) Allen-Hall L, Arnason JT, Cano P et al: Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB. J Ethnopharmacol. 2010 Feb 17;127(3):685-93. http://www.ncbi.nlm.nih.gov/pubmed/19995599
(33) García Giménez D, García Prado E, Sáenz Rodríguez T et al: Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing’s sarcoma and breast cancer cell lines. Planta Med. 2010 Feb;76(2):133-6. http://www.ncbi.nlm.nih.gov/pubmed/19724995
(34) Zeng K, Thompson KE, Yates CR et al: Synthesis and biological evaluation of quinic acid derivatives as anti- inflammatory agents. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5458-60.http://www.ncbi.nlm.nih.gov/pubmed/19674895
(35) Amaral S, Mira L, Nogueira JM et al: Plant extracts with anti-inflammatory properties–a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships. Bioorg Med Chem. 2009 Mar 1;17(5):1876-83. http://www.ncbi.nlm.nih.gov/pubmed/19201196
(36) Paniagua-Pérez R, Madrigal-Bujaidar E, Molina-Jasso D et al: Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine. Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):222-7.http://www.ncbi.nlm.nih.gov/pubmed/19175366
(37) Reis SR, Valente LM, Sampaio AL et al: Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. Int Immunopharmacol. 2008 Mar;8(3):468-76.http://www.ncbi.nlm.nih.gov/pubmed/18279801
(38) Pilarski R, Poczekaj-Kostrzewska M, Ciesiołka D et al: Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells. Pharmacol Rep. 2007 Sep-Oct;59(5):565-72.http://www.ncbi.nlm.nih.gov/pubmed/18048957
(39) Cheng AC, Jian CB, Huang YT et al: Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food Chem Toxicol. 2007 Nov;45(11):2206-18. http://www.ncbi.nlm.nih.gov/pubmed/17619071
(40) Ccahuana-Vasquez RA, Santos SS, Koga-Ito CY et al: Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Braz Oral Res. 2007 Jan-Mar;21(1):46-50. http://www.ncbi.nlm.nih.gov/pubmed/17426895
(41) García Prado E, García Gimenez MD, De la Puerta Vázquez R et al: Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine. 2007 Apr;14(4):280-4. http://www.ncbi.nlm.nih.gov/pubmed/17296291
(42) Frackowiak T, Baczek T, Roman K et al: Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40). Z Naturforsch C. 2006 Nov-Dec;61(11-12):821-6.http://www.ncbi.nlm.nih.gov/pubmed/17294693
(43) Hardin SR: Cat’s claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007 Feb;13(1):25-8. http://www.ncbi.nlm.nih.gov/pubmed/17210508
(44) Gonzales GF, Valerio LG Jr: Medicinal plants from Peru: a review of plants as potential agents against cancer. Anticancer Agents Med Chem. 2006 Sep;6():429-44. Review. http://www.ncbi.nlm.nih.gov/pubmed/17017852
(45) Allen-Hall L, Cano P, Arnason JT et al: Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha. J Ethnopharmacol. 2007 Jan 19;109(2):312-7.http://www.ncbi.nlm.nih.gov/pubmed/16959454
(46) Spelman K, Burns J, Nichols D et al: Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev. 2006 Jun;11(2):128-50. Review.http://www.ncbi.nlm.nih.gov/pubmed/16813462
(47) De Martino L, Martinot JL, Franceschelli S et al: Proapoptotic effect of Uncaria tomentosa extracts. J Ethnopharmacol. 2006 Aug 11;107(1):91-4. http://www.ncbi.nlm.nih.gov/pubmed/16569487
(48) Mammone T, Akesson C, Gan D et al: A water soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytother Res. 2006 Mar;20(3):178-83.http://www.ncbi.nlm.nih.gov/pubmed/16521105
(49) Bacher N, Tiefenthaler M, Sturm S et al: Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Br J Haematol. 2006 Mar;132(5):615-22. http://www.ncbi.nlm.nih.gov/pubmed/16445836
(50) Pilarski R, Zieliński H, Ciesiołka D et al: Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC. J Ethnopharmacol. 2006 Mar 8;104(1-2):18-23.http://www.ncbi.nlm.nih.gov/pubmed/16202551
(51) Styczynski J, Wysocki M; Alternative medicine remedies might stimulate viability of leukemic cells. Pediatr Blood Cancer. 2006 Jan;46(1):94-8. http://www.ncbi.nlm.nih.gov/pubmed/16047362
(52) García R, Cayunao C, Bocic R et al: Antimicrobial activity of isopteropodine. Z Naturforsch C. 2005 May-Jun;60(5-6):385-8. http://www.ncbi.nlm.nih.gov/pubmed/16042336
(53) Romero-Jiménez M, Campos-Sánchez J, Analla M et al: Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat Res. 2005 Aug 1;585(1-2):147-55.http://www.ncbi.nlm.nih.gov/pubmed/16005256.
(54) Setty AR, Sigal LH: Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum. 2005 Jun;34(6):773-84. Review.http://www.ncbi.nlm.nih.gov/pubmed/15942912
(55) Eberlin S, dos Santos LM, Queiroz ML: Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. Int Immunopharmacol. 2005 Jul;5(7-8):1235-46. http://www.ncbi.nlm.nih.gov/pubmed/15914328
(56) Jürgensen S, Dalbó S, Angers P et al: Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacol Biochem Behav. 2005 Jul;81(3):466-77. http://www.ncbi.nlm.nih.gov/pubmed/15907989
(57) Gonçalves C, Dinis T, Batista MT: Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 2005 Jan;66(1):89-98.http://www.ncbi.nlm.nih.gov/pubmed/15649515
(58) Heitzman ME, Neto CC, Winiarz E et al: Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry. 2005 Jan;66(1):5-29. Review. http://www.ncbi.nlm.nih.gov/pubmed/15649507
(59) Sheng Y, Akesson C, Holmgren K et al: An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol. 2005 Jan 15;96(3):577-84.http://www.ncbi.nlm.nih.gov/pubmed/15619581
(60) Cisneros FJ, Jayo M, Niedziela L: An Uncaria tomentosa (cat’s claw) extract protects mice against ozone-induced lung inflammation. J Ethnopharmacol. 2005 Jan 15;96(3):355-64.http://www.ncbi.nlm.nih.gov/pubmed/15619552
(61) Akesson C, Lindgren H, Pero RW et al: Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005 Jan;5(1):219-29.http://www.ncbi.nlm.nih.gov/pubmed/15589483
(62) Deharo E, Baelmans R, Gimenez A et al: In vitro immunomodulatory activity of plants used by the Tacana ethnic group in Bolivia. Phytomedicine. 2004 Sep;11(6):516-22. http://www.ncbi.nlm.nih.gov/pubmed/15500263
(63) Winkler C, Wirleitner B, Schroecksnadel K et al: In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells. Planta Med. 2004 Mar;70(3):205-10.http://www.ncbi.nlm.nih.gov/pubmed/15114496
(64) Akesson C, Lindgren H, Pero RW et al: An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int Immunopharmacol. 2003 Dec;3(13-14):1889-900.http://www.ncbi.nlm.nih.gov/pubmed/14636838
(65) Akesson Ch, Pero RW, Ivars F: C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003 Jan;10(1):23-33. http://www.ncbi.nlm.nih.gov/pubmed/12622460
(66) Kang TH, Matsumoto K, Tohda M et al: Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte. Eur J Pharmacol. 2002 May 24;444(1-2):39-45. http://www.ncbi.nlm.nih.gov/pubmed/12191580
(67) Sandoval M, Okuhama NN, Zhang XJ et al: Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002 May;9(4):325-37. http://www.ncbi.nlm.nih.gov/pubmed/12120814
(68) Aguilar JL, Rojas P, Marcelo A et al: Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). J Ethnopharmacol. 2002 Jul;81(2):271-6. http://www.ncbi.nlm.nih.gov/pubmed/12065162
(69) Mur E, Hartig F, Eibl G et al: Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol. 2002 Apr;29(4):678-81.http://www.ncbi.nlm.nih.gov/pubmed/11950006
(70) Williams JE: Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev. 2001 Dec;6(6):567-79. Review.http://www.ncbi.nlm.nih.gov/pubmed/11804547
(71) Riva L, Coradini D, Di Fronzo G et al: The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res. 2001 Jul-Aug;21(4A):2457-61.http://www.ncbi.nlm.nih.gov/pubmed/11724307
(72) Piscoya J, Rodriguez Z, Bustamante SA et al: Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442-8.http://www.ncbi.nlm.nih.gov/pubmed/11603848
(73) Sheng Y, Li L, Holmgren K et al: DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. http://www.ncbi.nlm.nih.gov/pubmed/11515717
(74) Lamm S, Sheng Y, Pero RW: Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine. 2001 Jul;8(4):267-74.http://www.ncbi.nlm.nih.gov/pubmed/11515716
(75) Muhammad I, Dunbar DC, Khan RA et al: Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa. Phytochemistry. 2001 Jul;57(5):781-5. http://www.ncbi.nlm.nih.gov/pubmed/11397448
(76) Muhammad I, Khan IA, Fischer NH et al: Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. Acta Crystallogr C. 2001 Apr;57(Pt 4):480-2.http://www.ncbi.nlm.nih.gov/pubmed/11313600
(77) Mohamed AF, Matsumoto K, Tabata K et al: Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test. J Pharm Pharmacol. 2000 Dec;52(12):1553-61. http://www.ncbi.nlm.nih.gov/pubmed/11197086
(78) Budzinski JW, Foster BC, Vandenhoek S et al: An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000 Jul;7(4):273-82.http://www.ncbi.nlm.nih.gov/pubmed/10969720
(79) Sandoval M, Charbonnet RM, Okuhama NN et al: Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med. 2000 Jul 1;29(1):71-8.http://www.ncbi.nlm.nih.gov/pubmed/10962207
(80) Sheng Y, Pero RW, Wagner H: Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43.http://www.ncbi.nlm.nih.gov/pubmed/10839217
(81) Sheng Y, Bryngelsson C, Pero RW: Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26.http://www.ncbi.nlm.nih.gov/pubmed/10687868
(82) Reinhard KH: Uncaria tomentosa (Willd.) D.C.: cat’s claw, uña de gato, or savéntaro. J Altern Complement Med. 1999 Apr;5(2):143-51. Review. http://www.ncbi.nlm.nih.gov/pubmed/10328636
(83) Lemaire I, Assinewe V, Cano P et al: Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (uña de gato) J Ethnopharmacol. 1999http://www.ncbi.nlm.nih.gov/pubmed/10197746
(84) Keplinger K, Laus G, Wurm M et al: Uncaria tomentosa (Willd.) DC.–ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmacol. 1999 Jan;64(1):23-34. Review.http://www.ncbi.nlm.nih.gov/pubmed/10075119
(85) Wurm M, Kacani L, Laus G et al: Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. Planta Med. 1998 Dec;64(8):701-4.http://www.ncbi.nlm.nih.gov/pubmed/9933988
(86) Sandoval-Chacón M, Thompson JH et al: Antiinflammatory actions of cat’s claw: the role of NF-kappaB. Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89. http://www.ncbi.nlm.nih.gov/pubmed/9882039
(87) Sheng Y, Pero RW, Amiri A et al: Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8.http://www.ncbi.nlm.nih.gov/pubmed/9858909
(88) Salazar EL, Jayme V: Depletion of specific binding sites for estrogen receptor by Uncaria tomentosa. Proc West Pharmacol Soc. 1998;41:123-4. http://www.ncbi.nlm.nih.gov/pubmed/9836266
(89) Wirth C, Wagner H: Pharmacologically active procyanidines from the bark of Uncaria tomentosa. Phytomedicine. 1997 Sep;4(3):265-6. http://www.ncbi.nlm.nih.gov/pubmed/23195487
(90) Santa Maria A, Lopez A, Diaz MM et al: Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro. J Ethnopharmacol. 1997 Aug;57(3):183-7. http://www.ncbi.nlm.nih.gov/pubmed/9292411
(91) Rizzi R, Re F, Bianchi A et al: Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol. 1993 Jan;38(1):63-77. http://www.ncbi.nlm.nih.gov/pubmed/8479203
(92) Aquino R, De Feo V, De Simone F et al: Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa. J Nat Prod. 1991 Mar-Apr;54(2):453-9. http://www.ncbi.nlm.nih.gov/pubmed/1919590
(93) Aquino R, De Simone F, Pizza C et al: Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Prod. 1989 Jul-Aug;52(4):679-85.http://www.ncbi.nlm.nih.gov/pubmed/2553871
(94) Senatore A, Cataldo A, Iaccarino FP et al: Phytochemical and biological study of Uncaria tomentosa. Boll Soc Ital Biol Sper. 1989 Jun;65(6):57-20. Italian. http://www.ncbi.nlm.nih.gov/pubmed/2611012
(95) Wagner H, Kreutzkamp B, Jurcic K: The alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action. Planta Med. 1985 Oct;(5):419-23. German. http://www.ncbi.nlm.nih.gov/pubmed/4080851
(96) Pero RW: Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering pruified quinic acid and/or carboxy alkyl ester. USPTO 8,372,449: Feb 12, 2013. http://1.usa.gov/1zVB81B
(97) Pero RW: Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester. USPTO 8,372,448: Feb 12, 2013. http://1.usa.gov/1FhM9MR
(98) Pero RW: Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester. USPTO 7,955,626: Jun 7, 2011. http://1.usa.gov/1H0AiO7
(99) Pero RW: Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals. USPTO 7,947,312: May 24, 2011. http://1.usa.gov/1RyQsa7
(100) Castillo GM et al: Composition and methods for treating Alzheimer’s disease and other amyloidosis. USPTO 7,754,250: Jul 13, 2010. http://1.usa.gov/1ATDh9d
(101) Castillo G et al: Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants. USPTO 7,314,642: Jan 1, 2008. http://1.usa.gov/1ATDfOC
(102) Pero RW: Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals. USPTO 6,964,784: Nov 15, 2005. http://1.usa.gov/1HbrwzA
(103) Bobrowski PJ: Methods and preparations of extracts of Uncaria species with reduced alkaloid content. USPTO 6,797,286: Sep 28, 2004. http://1.usa.gov/1KE5JRv
(104) Pero RW: Method of preparation and composition of a water soluble extract of the plant species uncaria. USPTO 6,039,949: Mar 21, 2000. http://1.usa.gov/1PE7P5A
(105) Keplinger K et al: Oxindole alkaloids having properties stimulating the immunologic system & preparation containing the same. USPTO 5,302,611: Apr 12, 1994. http://1.usa.gov/1QEYU6h
(106) Keplinger K et al: Oxindole alkaloids having properties stimulating the immunologic system and preparation containing the same. USPTO 4,940,725; Jul 10, 1990. http://1.usa.gov/1cMNpLM
(107) Keplinger K et al: Oxindole alkaloids having properties stimulating the immunologic system. USPTO 4,844,901: Jul 4, 1989. http://1.usa.gov/1PfTZeG