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Scientific Studies

(1) Mariani S, Lionetto L, Cavallari M et al: Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. Int J Mol Sci. 2014 Jan 21;15(1):1433-40.


(2) Daniels JA, Mulligan C, McCance D et al: A randomized controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes. Cardiovasc Diabetol. 2014 Jan 14; 13:16.


(3) Datta M, Taylor ML, Frizzell B: Dietary and serum lycopene levels in prostate cancer patients undergoing intensity- modulated radiation therapy. J Med Food. 2013 Dec;16(12):1131-7.


(4) Kesse-Guyot E, Andreeva VA, Ducros V et al: Carotenoid-rich dietary patterns during midlife and subsequent cognitive function. Br J Nutr. 2014 Mar 14;111(5):915-23.


(5) Zou ZY, Xu XR, Lin XM et al: Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2014 Feb;111(3):474-80.


(6) Chen J, Song Y, Zhang L: Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies. J Nutr Sci Vitaminol (Tokyo). 2013;59(3):213-23.


(7) Morgia G, Cimino S, Favilla V et al: Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of “FLOG” (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study. Int Braz J Urol. 2013 Mar-Apr;39(2):214-21.


(8) Sarkar PD, Gupt T, Sahu A Comparative analysis of lycopene in oxidative stress. J Assoc Physicians India. 2012 Jul;60:17-9.


(9) Karemore TV, Motwani M: Evaluation of the effect of newer antioxidant lycopene in the treatment of oral submucous fibrosis. Indian J Dent Res. 2012 Jul-Aug;23(4):524-8.


(10) Garrido M, González-Flores D, Marchena AM et al: A lycopene-enriched virgin olive oil enhances antioxidant status in humans. J Sci Food Agric. 2013 Jun;93(8):1820-6.


(11) Park E, Stacewicz-Sapuntzakis M, Sharifi R et al: Diet adherence dynamics and physiological responses to a tomato product whole-food intervention in African-American men. Br J Nutr. 2013 Jun 28;109(12):2219-30.


(12) Ghavipour M, Saedisomeolia A, Djalali M et al: Tomato juice consumption reduces systemic inflammation in overweight and obese females. Br J Nutr. 2013 Jun;109(11):2031-5.


(13) Wood LG, Garg ML, Smart JM et al: Manipulating antioxidant intake in asthma: a randomized controlled trial. Am J Clin Nutr. 2012 Sep;96(3):534-43.


(14) McEneny J, Wade L, Young IS et al: Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. J Nutr Biochem. 2013 Jan;24(1):163-8.


(15) Xaplanteris P, Vlachopoulos C, Pietri P et al: Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects. Nutr Res. 2012 May;32(5):390-4.


(16) Harms-Ringdahl M, Jenssen D, Haghdoost S: Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity. Nutr J. 2012 May 2;11:29.


(17) Saawarn N, Shashikanth MC, Saawarn S et al: Lycopene in the management of oral lichen planus: a placebo-controlled study. Indian J Dent Res. 2011 Sep-Oct;22(5):639-43.


(18) Burton-Freeman B, Talbot J, Park E et al: Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women. Mol Nutr Food Res. 2012 Apr;56(4):622-31.


(19) Riccioni G, Scotti L, Di Ilio E et al: Lycopene and preclinical carotid atherosclerosis. J Biol Regul Homeost Agents. 2011 Jul-Sep;25(3):435-41.


(20) Thyagarajan B, A Meyer K, Smith LJ et al: Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2011 Nov;94(5):1211-8.


(21) Magbanua MJ, Roy R, Sosa EV et al: Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One. 2011;6(9):e24004.


(22) Oborna I, Malickova K, Fingerova H et al: A randomized controlled trial of lycopene treatment on soluble receptor for advanced glycation end products in seminal and blood plasma of normospermic men. Am J Reprod Immunol. 2011 Sep;66(3):179-84.


(23) Kim JY, Paik JK, Kim OY et al: Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis. 2011 Mar;215(1):189-95.


(24) Shidfar F, Froghifar N, Vafa M et al: The effects of tomato consumption on serum glucose, apolipoprotein B, apolipoprotein A-I, homocysteine and blood pressure in type 2 diabetic patients. Int J Food Sci Nutr. 2011 May;62(3):289-94.


(25) Rizwan M, Rodriguez-Blanco I, Harbottle A et al: Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br J Dermatol. 2011 Jan;164(1):154-62.


(26) Zhang X, Wang Q, Neil B et al: Effect of lycopene on androgen receptor and prostate-specific antigen velocity. Chin Med J (Engl). 2010 Aug;123(16):2231-6.


(27) Mackinnon ES, Rao AV, Josse RG et al: Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Osteoporos Int. 2011 Apr;22(4):1091-101.


(28) Talvas J, Caris-Veyrat C, Guy L et al: Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.Am J Clin Nutr. 2010 Jun;91(6):1716-24.


(29) Puri T, Goyal S, Julka PK et al: Lycopene in treatment of high-grade gliomas: a pilot study. Neurol India. 2010 Jan-


(30) Darvin ME, Haag SF, Meinke MC et al: Determination of the influence of IR radiation on the antioxidative network of the human skin. J Biophotonics. 2011 Jan;4(1-2):21-9.


(31) Darvin ME, Haag S, Meinke M et al: Radical production by infrared A irradiation in human tissue. Skin Pharmacol Physiol. 2010;23(1):40-6.


(32) Tomita LY, Longatto Filho A, Costa MC etal: Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women. Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. Int J Cancer. 2010 Feb 1;126(3):703-14.


(33) Kramer MS, Kahn SR, Platt RW et al: Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm Epidemiology. 2009 Sep;20(5):707-13.


(34) Blume-Peytavi U, Rolland A, Darvin ME et al: Cutaneous lycopene and beta-carotene levels measured by resonance Raman spectroscopy: high reliability and sensitivity to oral lactolycopene deprivation and supplementation. Eur J Pharm Biopharm. 2009 Sep;73(1):187-94.


(35) Di Giacomo C, Acquaviva R, Sorrenti V et al: Oxidative and antioxidant status in plasma of runners: effect of oral supplementation with natural antioxidants. J Med Food. 2009 Feb;12(1):145-50.


(36) Paran E, Novack V, Engelhard YN et al: The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Drugs Ther. 2009 Apr;23(2):145-51.


(37) Devaraj S, Mathur S, Basu A et al: A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr. 2008 Apr;27(2):267-73.


(38) Hernández-Valero MA, Thomson CA, Hernández M et al: Comparison of baseline dietary intake of Hispanic and matched non-Hispanic white breast cancer survivors enrolled in the Women’s Healthy Eating and Living study. J Am Diet Assoc. 2008 Aug;108(8):1323-9.


(39) Grainger EM, Schwartz SJ, Wang S et al: A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutr Cancer. 2008;60(2):145-54.


(40) Dherani M, Murthy GV, Gupta SK et al: Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3328-35.


(41) Wood LG, Garg ML, Powell H et al: Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radic Res. 2008 Jan;42(1):94-102.


(42) Chandra RV, Prabhuji ML, Roopa DA et al: Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo- controlled clinical trial. Oral Health Prev Dent. 2007;5(4):327-36.


(43) Schwarz S, Obermüller-Jevic UC, Hellmis E et al: Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr. 2008 Jan;138(1):49-53.


(44) Neyestani TR, Shariatzadeh N, Gharavi A et al: Physiological dose of lycopene suppressed oxidative stress and enhanced serum levels of immunoglobulin M in patients with Type 2 diabetes mellitus: a possible role in the prevention of long-term complications. J Endocrinol Invest. 2007 Nov;30(10):833-8.


(45) Vrieling A, Voskuil DW, Bonfrer JM et al: Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am J Clin Nutr. 2007 Nov;86(5):1456-62.


(46) Thomson CA, Stendell-Hollis NR, Rock CL et al: Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2008-15.


(47) Vaishampayan U, Hussain M, Banerjee M et al: Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer. 2007;59(1):1-7.


(48) Shen YC, Chen SL, Wang CK: Contribution of tomato phenolics to antioxidation and down-regulation of blood lipids. J Agric Food Chem. 2007 Aug 8;55(16):6475-81.


(49) Silaste ML, Alfthan G, Aro A et al: Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br J Nutr. 2007 Dec;98(6):1251-8.


(50) Neyestani TR, Shariat-Zadeh N, Gharavi A et al: The opposite associations of lycopene and body fat mass with humoral immunity in type 2 diabetes mellitus: a possible role in atherogenesis. Iran J Allergy Asthma Immunol. 2007 Jun;6(2):79-87.


(51) Walfisch S, Walfisch Y, Kirilov E et al: Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev. 2007 Aug;16(4):298-303.


(52) Li Y, Zhang J: Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide. Nutr Neurosci. 2007 Feb-Apr;10(1-2):51-8.


(53) Graydon R, Gilchrist SE, Young IS et al: Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial. Eur J Clin Nutr. 2007 Oct;61(10):1196-200.


(54) Hozawa A, Jacobs DR Jr, Steffes MW et al: Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clin Chem. 2007 Mar;53(3):447-55.


(55) Kumar A, Bagewadi A, Keluskar V et al: Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Feb;103(2):207-13.


(56) Riso P, Brusamolino A, Martinetti A et al: Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects. Nutr Cancer. 2006;55(2):157-62.


(57) Barber NJ, Zhang X, Zhu G et al: Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.Prostate Cancer Prostatic Dis. 2006;9(4):407-13.


(58) Edinger MS, Koff WJ: Effect of the consumption of tomato paste on plasma prostate-specific antigen levels in patients with benign prostate hyperplasia. Braz J Med Biol Res. 2006 Aug;39(8):1115-9.


(59) Misra R, Mangi S, Joshi S et al: LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: a randomized controlled clinical trial. J Obstet Gynaecol Res. 2006 Jun;32(3):299-304.


(60) Hozawa A, Jacobs DR Jr, Steffes MW et al: Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol. 2006 May 15;163(10):929-37.


(61) Zhao X, Aldini G, Johnson EJ et al: Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr. 2006 Jan;83(1):163-9.


(62) Nouraie M, Pietinen P, Kamangar F et al: Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2087-92.


(63) JACC Study Group: Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study.J Epidemiol. 2005 Jun;15 Suppl 2:S140-9.


(64) JACC Study Group: Updated information on risk factors for lung cancer: findings from the JACC Study. J Epidemiol. 2005 Jun;15 Suppl 2:S134-9.


(65) van Breemen RB: How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia? J Nutr. 2005 Aug;135(8):2062S-4S.


(66) Bub A, Barth SW, Watzl B et al: Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in healthy young men on a low-carotenoid diet supplemented with tomato juice. Br J Nutr. 2005 Mar;93(3):291-7.


(67) Ansari MS, Gupta NP: Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol. 2004 Sep-Oct;22(5):415-20.


(68) Singh M, Krishanappa R, Bagewadi A et al: Efficacy of oral lycopene in the treatment of oral leukoplakia. Oral Oncol. 2004 Jul;40(6):591-6.


(69) Olfer’ev AM, Il’ina MV, Berzak NV et al: Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause. Vopr Pitan. 2004;73(1):19-23. (Russian).


(70) Tyssandier V, Feillet-Coudray C, Caris-Veyrat C et al: Effect of tomato product consumption on the plasma status of antioxidant microconstituents and on the plasma total antioxidant capacity in healthy subjects. J Am Coll Nutr. 2004 Apr;23(2):148-56.


(71) Mayne ST, Cartmel B, Lin H et al: Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers. J Am Coll Nutr. 2004 Feb;23(1):34-42.


(72) Astley SB, Hughes DA, Wright AJ et al: DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo. Br J Nutr. 2004 Jan;91(1):53-61.


(73) Cardinault N, Tyssandier V, Grolier P et al: Comparison of the postprandial chylomicron carotenoid responses in young and older subjects. Eur J Nutr. 2003 Dec;42(6):315-23.


(74) Hoppe PP, Krämer K, van den Berg H et al: Synthetic and tomato-based lycopene have identical bioavailability in humans. Eur J Nutr. 2003 Oct;42(5):272-8.


(75) Watzl B, Bub A, Briviba K et al: Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men. Ann Nutr Metab. 2003;47(6):255-61.


(76) Ansari MS, Gupta NP: A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2003 Sep;92(4):375-8.


(77) Césarini JP, Michel L, Maurette JM et al: Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed. 2003 Aug;19(4):182-9.


(78) Visioli F, Riso P, Grande S et al: Protective activity of tomato products on in vivo markers of lipid oxidation. Eur J Nutr. 2003 Aug;42(4):201-6.


(79) Gupta NP, Kumar R: Lycopene therapy in idiopathic male infertility–a preliminary report. Int Urol Nephrol. 2002;34(3):369-72.


(80) Sharma JB, Kumar A, Kumar A et al: Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol Obstet. 2003 Jun;81(3):257-62.


(81) JACC Study Group: Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Cancer Sci. 2003 Jan;94(1):57-63.


(82) Djuric Z, Uhley VE, Naegeli L et al: Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. Nutrition. 2003 Mar;19(3):244-9.


(83) Hadley CW, Clinton SK, Schwartz SJ: The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J Nutr. 2003 Mar;133(3):727-32.


(84) Heinrich U, Gärtner C, Wiebusch M et al: Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr. 2003 Jan;133(1):98-101.


(85) Bub A, Barth S, Watzl B et al: Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in R-allele-carrier but not in QQ homozygous elderly subjects on a tomato-rich diet. Eur J Nutr. 2002 Dec;41(6):237-43.


(86) Arab L, Steck-Scott S, Fleishauer AT: Lycopene and the lung. Exp Biol Med (Maywood). 2002 Nov;227(10):894-9.


(87) Kucuk O, Sarkar FH, Djuric Z et al: Effects of lycopene supplementation in patients with localized prostate cancer. Exp Biol Med (Maywood). 2002 Nov;227(10):881-5.


(88) Vogt TM, Mayne ST, Graubard BI et al: Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. Am J Epidemiol. 2002 Jun 1;155(11):1023-32.


(89) Maruyama C, Imamura K, Oshima S et al: Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. J Nutr Sci Vitaminol (Tokyo). 2001 Jun;47(3):213-21.


(90) Kucuk O, Sarkar FH, Sakr W et al: Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Biomarkers Prev. 2001 Aug;10(8):861-8.


(91) Mucci LA, Tamimi R, Lagiou P et al: Are dietary influences on the risk of prostate cancer mediated through the insulin- like growth factor system? BJU Int. 2001 Jun;87(9):814-20.


(92) Stahl W, Heinrich U, Wiseman S et al: Dietary tomato paste protects against ultraviolet light-induced erythema in humans. J Nutr. 2001 May;131(5):1449-51.


(93) Neuman I, Nahum H, Ben-Amotz A; Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy. 2000 Dec;55(12):1184-9.


(94) Chopra M, O’Neill ME, Keogh N et al: Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Clin Chem. 2000 Nov;46(11):1818-29.


(95) Hughes DA, Wright AJ, Finglas PM et al: Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers. J Infect Dis. 2000 Sep;182 Suppl 1:S11-5.


(96) Torbergsen AC, Collins AR : Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr. 2000 Apr;39(2):80-5.


(97) Upritchard JE, Sutherland WH, Mann JI et al: Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care. 2000 Jun;23(6):733-8.


(98) Riso P, Pinder A, Santangelo A et al: Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Am J Clin Nutr. 1999 Apr;69(4):712-8.

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